Idra-21 Kognitivni prahje pozitivan alosterični regulator AMPA receptora i derivat benzotiadiazola. To je kiralni molekul u kojem je ( plus ) - IDRA-21 aktivni oblik.
Kako se IDRA-21 ponašao u eksperimentima na životinjama?
U studiji o promicanju inteligencije kod životinja,IDRA-21 prahznačajno poboljšala sposobnost učenja i pamćenja. U poništavanju kognitivnih deficita uzrokovanih dugotrajnom upotrebom alprazolama ili skopolamina, on je oko 10-30 puta jači od aniracetama. Najnevjerovatnija stvar je njegovo vrijeme metabolizma lijeka: proučavano je da proizvodi trajne efekte koji traju i do 48 sati nakon jedne primjene. Istraživači kažu da će mehanizam ovog efekta vjerovatno biti kroz promoviranje dugoročnog poboljšanja između moždanih sinapsi.
Koji je proces istraživanja droga za poboljšanje kognitivnih sposobnosti? Kako je biloIDRA-21rođen?
In 1990, neuroscientist Eric Kandel discovered a brain chemical called cyclic adenosine monophosphate response element-binding protein (CREB), which is a key factor in memory formation. In 1994, neuroscientists Tim Tully and Jerry Yin adjusted the way CREB works in a fruit fly. When learning new habits, fruit flies with enhanced CREB were 10 times faster than their unchanged counterparts. Later, other researchers got the same results in mice. In 1999, Qian Zhuo, a neuroscientist at Princeton University, created a mouse with more pairs of NR2B genes, which can coordinate the activity of synaptic receptors in the brain. In memory and learning tests, NR2B enhanced mice performed five times better than unmodified mice. After 2000, many new pharmaceutical companies competed to apply these findings to humans. Both memory pharmaceutical and helikongshan medical are conducting clinical trials of drugs related to CREB. Another COLTEX pharmaceutical company is developing a brain chemical called ampakine to achieve similar effects through another neural pathway. Among so many research institutions, Jingsi pharmaceutical （Abbreviation: IDRA） has developed IDRA-21 through step-by-step analogy research. At the same time, there are many sister products of this product, which have been eliminated for various reasons.